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Human smoothened 7TM receptor in complex with an antitumor agent

Organism: Homo sapiens
Model: Experimental
Representation: Coarse-grained
Type: α-helical

Pfam Acc: PF01534
PDB ID: 4JKV


Membrane assignment:

Output PDB file Download

Hydrophobic thickness = 35.0 Å

Number of TM segments = 14

Sequence positions:
A: 148-172|182-209|231-259|275-295|315-341|367-390|419-441
B: 601-626|635-659|684-712|722-742|762-787|815-839|866-889

Tilt angles:
A - Segment: 148-172 - Tilt: 25.0°
A - Segment: 182-209 - Tilt: 26.7°
A - Segment: 231-259 - Tilt: 44.3°
A - Segment: 275-295 - Tilt: 8.8°
A - Segment: 315-341 - Tilt: 26.6°
A - Segment: 367-390 - Tilt: 11.5°
A - Segment: 419-441 - Tilt: 11.9°
B - Segment: 601-626 - Tilt: 29.7°
B - Segment: 635-659 - Tilt: 31.4°
B - Segment: 684-712 - Tilt: 36.3°
B - Segment: 722-742 - Tilt: 9.4°
B - Segment: 762-787 - Tilt: 19.7°
B - Segment: 815-839 - Tilt: 20.5°
B - Segment: 866-889 - Tilt: 22.1°


Structural assessment:

MAIDEN score = -166.4213
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.


Scores for all residue pairs Download




[creation date: Sep-08-2016]