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Active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo

Organism: Homo sapiens
Model: Experimental
Representation: Coarse-grained
Type: α-helical

Pfam Acc: PF00001
PDB ID: 4MQS


Membrane assignment:

Output PDB file Download

Hydrophobic thickness = 33.0 Å

Number of TM segments = 7

Sequence positions:
A: 7-28|43-66|73-97|126-153|158-186|207-234|240-264

Tilt angles:
A - Segment: 7-28 - Tilt: 17.3°
A - Segment: 43-66 - Tilt: 3.0°
A - Segment: 73-97 - Tilt: 34.4°
A - Segment: 126-153 - Tilt: 13.7°
A - Segment: 158-186 - Tilt: 36.0°
A - Segment: 207-234 - Tilt: 34.8°
A - Segment: 240-264 - Tilt: 24.5°


Structural assessment:

MAIDEN score = -60.9274
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.


Scores for all residue pairs Download




[creation date: Sep-08-2016]