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Human GPR40 bound to allosteric agonist TAK-875

Organism: Homo sapiens
Model: Experimental
Representation: Coarse-grained
Type: α-helical

Pfam Acc: PF00001
PDB ID: 4PHU


Membrane assignment:

Output PDB file Download

Hydrophobic thickness = 33.3 Å

Number of TM segments = 7

Sequence positions:
A: 7-28|43-66|74-102|116-144|168-196|377-403|411-433

Tilt angles:
A - Segment: 7-28 - Tilt: 14.8°
A - Segment: 43-66 - Tilt: 15.8°
A - Segment: 74-102 - Tilt: 40.7°
A - Segment: 116-144 - Tilt: 23.9°
A - Segment: 168-196 - Tilt: 33.0°
A - Segment: 377-403 - Tilt: 30.8°
A - Segment: 411-433 - Tilt: 26.8°


Structural assessment:

MAIDEN score = -17.5405
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.


Scores for all residue pairs Download




[creation date: Sep-08-2016]