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Lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazole

Organism: Saccharomyces cerevisiae
Model: Experimental
Representation: Coarse-grained
Type: α-helical

Pfam Acc: PF00067
PDB ID: 5EQB


Membrane assignment:

Output PDB file Download

Hydrophobic thickness = 27.6 Å

Number of TM segments = 5

Sequence positions:
A: 12-72|82-129|145-177|192-253|301-318

Tilt angles:
A - Segment: 12-72 - Tilt: 60.2°
A - Segment: 82-129 - Tilt: 54.8°
A - Segment: 145-177 - Tilt: 46.1°
A - Segment: 192-253 - Tilt: 2.7°
A - Segment: 301-318 - Tilt: 5.4°


Structural assessment:

MAIDEN score = 17.2756
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.


Scores for all residue pairs Download




[creation date: Sep-08-2016]