Gamma secretase in complex with a drug DAPT
Organism: Homo sapiens
Model: Experimental
Representation: Atomistic
Type: α-helical
Pfam Acc: PF01080
PDB ID: 5FN2
Membrane assignment:
Output PDB file Download
Hydrophobic thickness = 27.9 Å
Number of TM segments = 18
Sequence positions:
A: 674-692
C: 7-27|31-53|74-93|116-135|161-182|186-203|214-232
B: 83-101|132-153|160-183|195-215|217-241|243-261|381-397|403-421|432-454
D: 57-75
Tilt angles:
A - Segment: 674-692 - Tilt: 10.3°
C - Segment: 7-27 - Tilt: 10.3°
C - Segment: 31-53 - Tilt: 40.3°
C - Segment: 74-93 - Tilt: 20.0°
C - Segment: 116-135 - Tilt: 22.7°
C - Segment: 161-182 - Tilt: 37.0°
C - Segment: 186-203 - Tilt: 19.3°
C - Segment: 214-232 - Tilt: 3.6°
B - Segment: 83-101 - Tilt: 12.1°
B - Segment: 132-153 - Tilt: 33.8°
B - Segment: 160-183 - Tilt: 31.0°
B - Segment: 195-215 - Tilt: 13.3°
B - Segment: 217-241 - Tilt: 44.6°
B - Segment: 243-261 - Tilt: 9.3°
B - Segment: 381-397 - Tilt: 18.1°
B - Segment: 403-421 - Tilt: 14.0°
B - Segment: 432-454 - Tilt: 32.9°
D - Segment: 57-75 - Tilt: 6.2°
Structural assessment:
MAIDEN score = -194.6254
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.
Scores for all residue pairs Download
[creation date: Sep-08-2016]