Gamma secretase in complex with a drug DAPT
Organism: Homo sapiens
Model: Experimental
Representation: Coarse-grained
Type: α-helical
Pfam Acc: PF01080
PDB ID: 5FN2
Membrane assignment:
Output PDB file Download
Hydrophobic thickness = 22.2 Å
Number of TM segments = 18
Sequence positions:
A: 643-658
C: 975-991|997-1018|1039-1055|1083-1097|1128-1143|1152-1166|1181-1195
B: 673-687|720-737|749-767|786-801|808-826|832-845|881-895|903-917|934-948
D: 1264-1279
Tilt angles:
A - Segment: 643-658 - Tilt: 10.1°
C - Segment: 975-991 - Tilt: 12.8°
C - Segment: 997-1018 - Tilt: 49.4°
C - Segment: 1039-1055 - Tilt: 26.0°
C - Segment: 1083-1097 - Tilt: 25.2°
C - Segment: 1128-1143 - Tilt: 25.0°
C - Segment: 1152-1166 - Tilt: 22.9°
C - Segment: 1181-1195 - Tilt: 10.9°
B - Segment: 673-687 - Tilt: 10.6°
B - Segment: 720-737 - Tilt: 37.4°
B - Segment: 749-767 - Tilt: 35.8°
B - Segment: 786-801 - Tilt: 20.6°
B - Segment: 808-826 - Tilt: 45.5°
B - Segment: 832-845 - Tilt: 12.6°
B - Segment: 881-895 - Tilt: 27.9°
B - Segment: 903-917 - Tilt: 13.6°
B - Segment: 934-948 - Tilt: 35.5°
D - Segment: 1264-1279 - Tilt: 12.3°
Structural assessment:
MAIDEN score = -105.6768
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.
Scores for all residue pairs Download
[creation date: Sep-08-2016]