Ras suppressor protein 1 (RSU1)
The protein contains 277 amino acids for an estimated molecular weight of 31540 Da.
Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro. (updated: Feb. 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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Biological Process
Cell junction assembly
Positive regulation of cell-substrate adhesion
Positive regulation of GTPase activity
Positive regulation of neural precursor cell proliferation
Ras protein signal transduction
Signal transduction
Molecular Function
The reference OMIM entry for this protein is 179555
Ras suppressor protein 1; rsu1
CLONING
Cutler et al. (1992) isolated mouse Rsu1 (formerly referred to as Rsp1), a novel cDNA capable of suppressing Ki-ras transformation. They showed that Rsu1 is phylogenetically conserved and ubiquitously expressed, suggesting that it may interact with other highly conserved proteins and function in a Ras signal transduction pathway in higher eukaryotes. Tsuda and Cutler (1993) isolated human RSU1 cDNA from a lambda gt10 primary skin fibroblast cDNA library and showed that the human protein exhibits more than 95% conservation with the murine Rsu1 protein.MAPPING
By hybridization of a human RSU1 cDNA probe to a set of hamster-human somatic cell hybrids, Tsuda and Cutler (1993) assigned the RSU1 gene to chromosome 10. Because several neoplastic disease loci had been mapped to chromosome 10, Tsuda and Cutler (1993) raised the question of RSU1 involvement in neoplastic disease. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 179555 was added.