Tumor protein p63-regulated gene 1-like protein (TPRG1L)
The protein contains 272 amino acids for an estimated molecular weight of 30212 Da.
Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release. (updated: Nov. 7, 2018)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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No binding partner found
The reference OMIM entry for this protein is 611460
Family with sequence similarity 79, member a; fam79a
Mover
CLONING
Using a yeast 2-hybrid screen to search for presynaptic proteins with the sequence of bassoon (BSN; 604020), a vertebrate-specific scaffolding protein of the cytomatrix of active zones (CAZ), as bait, Kremer et al. (2007) identified a novel mouse cDNA, which they designated Mover. The deduced 266-amino acid mouse protein has no transmembrane domains or putative anchor sites. It is 91% identical with the human ortholog, FAM79A, which contains 272 amino acids. Database analysis revealed that the gene is present only in vertebrate genomes. Northern blot analysis of rat tissues detected high expression in brain and lower expression in heart, liver, kidney, and testis.GENE FUNCTION
Using tagged recombinant Mover constructs, Kremer et al. (2007) showed that the protein colocalized with synaptophysin (SYP; 313475), an integral protein of synaptic vesicles. Using antisera to the Mover protein, they found that Mover was most abundant in brain and colocalized with presynaptic markers in the calyx of Held, a giant synaptic terminal that forms around the soma of principal cells in the medial nucleus of the trapezoid body. It was also seen in mossy fiber terminals of the hippocampus and in inhibitory terminals of the cerebellar cortex. However, it was not seen in inhibitory neurons of the hippocampus. Because of its restricted distribution, Kremer et al. (2007) proposed that Mover may function as an effector for CAZ-proteins in specific sets of vertebrate synapses.MAPPING
The International Radiation Hybrid Mapping Consortium mapped the FAM79A gene to chromosome 1 (TMAP RH17152). ... More on the omim web site
Nov. 16, 2018: Protein entry updated
Automatic update: Entry updated from uniprot information.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 611460 was added.