Cell death regulator Aven (AVEN)
The protein contains 362 amino acids for an estimated molecular weight of 38506 Da.
Protects against apoptosis mediated by Apaf-1. (updated: March 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs2241647 |
Biological Process
Apoptotic process
Negative regulation of apoptotic process
Negative regulation of G2/M transition of mitotic cell cycle
Molecular Function
The reference OMIM entry for this protein is 605265
Apoptosis and caspase activation inhibitor; aven
Cell death regulator aven
CLONING
BCLXL (600039), an antiapoptotic BCL2 family member, is postulated to function at multiple stages in the cell death pathway. The possibility that BCLXL inhibits cell death at a late (postmitochondrial) step in the death pathway was supported by the study of Chau et al. (2000). Using a yeast 2-hybrid screen of a B-cell cDNA library, they identified a novel apoptosis inhibitor, which they termed AVEN (derived from 'Aventine,' a Roman stronghold), that binds to both BCLXL and the caspase regulator APAF1 (602233). The AVEN gene encodes a 362-amino acid protein and is conserved in other mammalian species. Northern blot analysis detected a 1.7-kb AVEN transcript in all adult tissues tested, with highest expression in heart, skeletal muscle, kidney, liver, pancreas, and testis; a number of cell lines also expressed AVEN. Only those mutants of BCLXL that retained their antiapoptotic activity were capable of binding AVEN. AVEN was shown to interfere with the ability of APAF1 to self-associate, suggesting that AVEN impairs APAF1-mediated activation of caspases. Consistent with this idea, AVEN inhibited the proteolytic activation of caspases in a cell-free extract and suppressed apoptosis induced by APAF1 plus caspase-9 (CASP9; 602234). Thus, AVEN represents a novel class of cell death regulator.MAPPING
By genomic sequencing, Chau et al. (2000) mapped the AVEN gene to chromosome 15. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 605265 was added.