Myelin protein zero-like protein 1 (MPZL1)
The protein contains 269 amino acids for an estimated molecular weight of 29082 Da.
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is predicted to be membranous by TOPCONS.
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No binding partner found
The reference OMIM entry for this protein is 604376
Myelin protein zero-like 1; mpzl1
Protein zero-related; pzr
CLONING
Protein tyrosine phosphatases (PTP) have a pivotal role in cell proliferation, differentiation, and transformation. Zhao and Zhao (1998) identified a 43-kD hyperphosphorylated membrane glycoprotein that has a specific and near-stoichiometric association with PTPN11 (176876), a positive transducer of growth factor signal transduction. The 43-kD protein could be dephosphorylated by PTPN11 but not by PTPN6 (176883), which has a negative role in the proliferation of hematopoietic cells. By EST database searching and PCR RACE on 3 cDNA libraries (kidney, HeLa, and 293 cells), Zhao and Zhao (1998) isolated a cDNA encoding the predicted 269-amino acid protein, which they called PZR for protein zero-related. Sequence homology analysis revealed 45.8% identity with myelin protein zero (159440). The predicted protein contains an amino-terminal signal sequence and a single membrane-spanning segment. The extracellular portion forms an Ig-like domain with potential N-linked glycosylation sites. The intracellular portion contains an ITIM consensus sequence, a motif observed in another potential PTPN11 substrate, PTPNS1 (602461). Northern blot analysis revealed expression of PZR as a major, approximately 4.0-kb transcript and minor 3.8- and 1.3-kb transcripts in all tissues tested, with highest expression in heart, placenta, kidney, and pancreas. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 604376 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).