Vitronectin (VTN)

The protein contains 478 amino acids for an estimated molecular weight of 54306 Da.

 

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.', 'Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. (updated: Oct. 10, 2018)

Protein identification was indicated in the following studies:

  1. Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
  2. D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete		TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.
Protein sequence (FASTA)
Protein coevolution profile (FreeContact)
Multiple Sequence Alignment (Muscle)

Interpro domains
Total structural coverage: 0%
Model score: 0
No model available.

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VariantDescription
dbSNP:rs2227741
dbSNP:rs2227723
dbSNP:rs704

The reference OMIM entry for this protein is 193190

Vitronectin; vtn
Serum spreading factor
Complement s-protein
Somatomedin b

DESCRIPTION

Vitronectin, also called serum spreading factor or complement S-protein, is a 75-kD glycoprotein in plasma and tissue. It is a multifunctional protein that mediates cell-to-substrate adhesion, inhibits the cytolytic action of the terminal complement cascade in vitro, and binds to several serine protease inhibitors of the serpin family, e.g., antithrombin III (AT3; 107300), plasminogen activator inhibitors I and II (PAI1, 173360; PAI2, 173390), heparin cofactor II (HCF2; 142360), and protease nexin (PN1; 177010) (summary by Fink et al., 1992).

CLONING

The primary structure of vitronectin has been deduced from the sequence of its cloned cDNA (Jenne and Stanley, 1985; Preissner et al., 1986). The deduced protein contains 459 amino acides preceded by a cleaved leader peptide of 19 residues.

MAPPING

By use of high resolution fluorescence in situ hybridization (FISH), Fink et al. (1992) mapped the VTN gene to chromosome 17q11. The localization was confirmed by cohybridization with a centromere-specific alphoid probe.

MOLECULAR GENETICS

Polymorphism of vitronectin of plasma has been demonstrated (Conlon et al., 1988; Kubota et al., 1988). Sun and Mosher (1989) demonstrated that the frequencies are different in Orientals and Caucasians.

NOMENCLATURE

S-protein is not to be confused with protein S (176880). ... More on the omim web site

Subscribe to this protein entry history

July 1, 2020: Protein entry updated
Automatic update: OMIM entry 193190 was added.

Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).