Guanine nucleotide-binding protein G(z) subunit alpha (GNAZ)
The protein contains 355 amino acids for an estimated molecular weight of 40924 Da.
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology.
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Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway
Protein folding
The reference OMIM entry for this protein is 139160
Guanine nucleotide-binding protein, alpha z polypeptide; gnaz
CLONING
By cDNA cloning, Blatt et al. (1988) identified a G protein-encoding gene which they called G(z-alpha) and symbolized GNAZ. The corresponding protein was found to differ strikingly from other G-alpha subunits in amino acid sequence in a number of regions, and it appeared to be highly enriched in neural tissue (Fong et al., 1988; Matsuoka et al., 1988).MAPPING
Blatt et al. (1988) assigned the GNAZ locus to chromosome 22 by hybridization to the DNA from a panel of rodent-human cell hybrids. By in situ hybridization, Wilkie et al. (1992) demonstrated that the GNAZ gene is located in band 22q11. By the analysis of RFLVs in an interspecific backcross, they showed that the corresponding gene is located on mouse chromosome 10. Budarf et al. (1991) further narrowed the localization to 22q11.2 by fluorescence in situ hybridization on reverse banded metaphase chromosomes. They confirmed the localization by means of a regional mapping panel of somatic cell hybrids. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 139160 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).