60S ribosomal protein L37a (RPL37A)
The protein contains 92 amino acids for an estimated molecular weight of 10275 Da.
No function (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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Biological Process
Cytoplasmic translation
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
RRNA processing
SRP-dependent cotranslational protein targeting to membrane
Translation
Translational initiation
Viral transcription
The reference OMIM entry for this protein is 613314
Ribosomal protein l37a; rpl37a
DESCRIPTION
RPL37A encodes a protein component of the large ribosomal subunit (Sim et al., 2010).CLONING
Saha et al. (1993) obtained a partial clone homologous to rat Rpl37a from a human neuroblastoma cell line cDNA library, and by RT-PCR, they obtained the full-length human RPL37A clone. The 5-prime terminus contains a CTTTCC-like sequence characteristic of transcripts encoding ribosomal proteins. The deduced 92-amino acid protein has a calculated molecular mass of 10.3 kD. It is highly basic and contains a putative zinc finger domain. The human and rat transcripts share 85% nucleotide identity, and the proteins are 100% identical. Northern blot analysis detected RPL37A expression in normal human lymphocytes and in human neuroblastoma and Molt4 cells. Variable Rpl37a expression was detected in all rat tissues examined.GENE FUNCTION
Using RT-PCR, Sim et al. (2010) found that a subset of genes encoding proteins of the large ribosomal subunit was differentially expressed in nasopharyngeal carcinoma (see 607107) cell lines compared with a normal nasopharyngeal epithelial cell line. RPL37A was 1 of 3 genes significantly downregulated in the carcinoma cell lines.MAPPING
Hartz (2010) mapped the RPL37A gene to chromosome 2q35 based on an alignment of the RPL37A sequence (GenBank GENBANK BC000555) with the genomic sequence (GRCh37). ... More on the omim web site
Nov. 16, 2018: Protein entry updated
Automatic update: OMIM entry 613314 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).