SPRY domain-containing protein 7 (SPRYD7)
The protein contains 196 amino acids for an estimated molecular weight of 21666 Da.
No function (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
(right-click above to access to more options from the contextual menu)
No binding partner found
No information from the Gene Ontology is available for this entry.
The reference OMIM entry for this protein is 607866
Chromosome 13 open reading frame 1; c13orf1
Chronic lymphocytic leukemia deletion region gene 6; clld6
CLONING
Mabuchi et al. (2001) assembled a high-resolution physical map spanning the critical region deleted in B-cell chronic lymphocytic leukemia (109543) on chromosome 13q14 and identified CLLD6. The deduced 196-amino acid protein has a calculated molecular mass of about 22 kD. Northern blot analysis detected transcripts of 1.1, 1.5, and 3.1 kb in all normal tissues and tumor cell lines examined, with highest levels in heart, skeletal muscle, and testis, and lowest levels in thymus, peripheral blood leukocytes, lymph node, and bone marrow. The different transcripts result from the use of alternate polyadenylation sites.GENE STRUCTURE
Mabuchi et al. (2001) determined that the CLLD6 gene contains 5 exons and spans 24 kb.MAPPING
By genomic sequence analysis, Mabuchi et al. (2001) mapped the CLLD6 gene to chromosome 13q14. ... More on the omim web site
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 607866 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).