Histone H2A type 2-A (HIST2H2AA4)
The protein contains 130 amino acids for an estimated molecular weight of 14095 Da.
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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No binding partner found
The reference OMIM entry for this protein is 142720
Histone gene cluster 2, h2a histone family, member a3; hist2h2aa3
Histone gene cluster 2, h2aa3
Hist2 cluster, h2aa3
H2a histone family, member o; h2afo
H2a/o
H2a.2
Hist2h2aa
For background information on histones, histone gene clusters, and the H2A histone family, see HIST1H2AA (613499).
CLONING
Marashi et al. (1984) identified a DNA segment containing 1 copy of each core histone, including H2A and H2B pseudogenes. Mannironi et al. (1994) cloned an H2A gene from this cluster and called it H2A.2. Albig and Doenecke (1997) designated this gene H2A/O.MAPPING
By in situ hybridization, Allen et al. (1991) mapped the histone gene cluster containing the HIST2H2AA3 gene to chromosome 1q21. By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 1q21, which they called histone gene cluster-2 (HIST2), contains 6 histone genes, including HIST2H2AA3.GENE FUNCTION
See HIST1H2AA (613499) for functional information on H2A histones. ... More on the omim web site
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 142720 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).