Butyrophilin subfamily 2 member A1 (BTN2A1)
The protein contains 527 amino acids for an estimated molecular weight of 59633 Da.
No function (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology, is predicted to be membranous by TOPCONS.
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| Variant | Description |
|---|---|
| dbSNP:rs3734539 | |
| dbSNP:rs13195402 | |
| dbSNP:rs13195401 | |
| dbSNP:rs13195509 | |
| dbSNP:rs3734542 | |
| dbSNP:rs3734543 |
Biological Process
Adaptive immune response
Lipid metabolic process
Regulation of cytokine production
Regulation of immune response
T cell receptor signaling pathway
Cellular Component
External side of plasma membrane
Integral component of plasma membrane
Plasma membrane
The reference OMIM entry for this protein is 613590
Butyrophilin, subfamily 2, member a1; btn2a1
Bt2.1
Btf1
DESCRIPTION
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (601610) and the BTN2 (e.g., BTN2A1) and BTN3 (e.g., BNT3A1; 613593) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010).CLONING
By genomic sequence analysis, RT-PCR of peripheral blood leukocytes and human cell lines, and 3-prime RACE of a fetal tissue cDNA library, Rhodes et al. (2001) cloned BTN2A1. They also identified alternative splicing affecting the 3-prime end of BTN2A1. Immunofluorescence microscopy showed surface expression of BTN2A1 in transfected HeLa and Chinese hamster ovary cells.GENE STRUCTURE
Rhodes et al. (2001) determined that the BTN2A1 gene spans approximately 12 kb and contains 7 coding exons.MAPPING
By genomic sequence analysis, Rhodes et al. (2001) mapped the BTN2A1 gene within the BTN gene cluster on chromosome 6p22.1. The BTN gene cluster is located about 4 Mb telomeric to the classical MHC class I genes. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 613590 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).