Endoplasmic reticulum metallopeptidase 1 (ERMP1)
The protein contains 904 amino acids for an estimated molecular weight of 100231 Da.
Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. (updated: Oct. 31, 2006)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is predicted to be membranous by TOPCONS.
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| Variant | Description |
|---|---|
| dbSNP:rs13284203 |
No binding partner found
Biological Process
Cellular response to oxidative stress
Endoplasmic reticulum unfolded protein response
Proteolysis
The reference OMIM entry for this protein is 611156
Endoplasmic reticulum metallopeptidase 1; ermp1
Fxna, rat, homolog of
Kiaa1815
CLONING
By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2001) cloned a novel human cDNA, which they designated KIAA1815. By differential display in the neonatal rat ovary, Garcia-Rudaz et al. (2007) identified a novel cDNA, termed Fxna (Felix-ina), expressed during folliculogenesis. Northern blot analysis detected wide expression of Fxna in rat tissues, with highest levels in ovary, kidney, hypothalamus, and hippocampus. Sequence analysis showed that Fxna is a member of the metallopeptidase family M28. It contains at least 8 transmembrane domains near the C terminus, suggesting that it is a membrane protein, and a peptidase domain near the N terminus. Transfection experiments in COS-7 cells localized Fxna to the endoplasmic reticulum.GENE FUNCTION
By in situ analysis of rat ovaries collected 48 hours after birth, Garcia-Rudaz et al. (2007) showed that Fxna was expressed in granulosa cells surrounding the oocytes but not in the oocytes themselves. Down-regulation of the gene with a lentiviral siRNA disrupted both the rate of follicle assembly and the initiation of follicle growth. There was a widespread loss of somatic germ cell organization in which pregranulosa cells encircled more than one oocyte and many oocytes were not surrounded by somatic cells.MAPPING
The International Radiation Hybrid Mapping Consortium mapped the ERMP1 gene to chromosome 9 (TMAP WI-15054). Scott (2007) mapped the ERMP1 gene to chromosome 9p24 based on an alignment of the ERMP1 sequence (GenBank GENBANK AK093217) with the genomic sequence (build 36.2). ... More on the omim web site
Oct. 19, 2018: Protein entry updated
Automatic update: OMIM entry 611156 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).