Vesicle-trafficking protein SEC22a (SEC22A)
The protein contains 307 amino acids for an estimated molecular weight of 34948 Da.
May be involved in vesicle transport between the ER and the Golgi complex. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is predicted to be membranous by TOPCONS.
(right-click above to access to more options from the contextual menu)
No binding partner found
The reference OMIM entry for this protein is 612442
Secretion deficient 22, s. cerevisiae, homolog of, a; sec22a
Sec22l2
CLONING
The S. cerevisiae Sec22, Bet1 (605456), and Bos1 genes encode interacting proteins that play a role in endoplasmic reticulum (ER)-Golgi transport. Using human brain cDNA sequences homologous to yeast Sec22 and Bet1 to screen a rat liver cDNA library, Hay et al. (1996) cloned rat homologs of both yeast genes. The rat SEC22 cDNA, later designated SEC22A, encodes a deduced 254-amino acid integral membrane protein with a predicted molecular mass of 28.5 kD and a transmembrane domain at or near the C terminus. The rat and yeast proteins share 32% overall sequence identity. Northern blot analysis detected a 2.6-kb transcript in all 7 rat tissues tested, with predominant expression in lung and liver. Immunofluorescence microscopy of epitope-tagged SEC22A in transfected COS cells demonstrated localization in the endoplasmic reticulum.MAPPING
Gross (2015) mapped the SEC22A gene to chromosome 3q21.1 based on an alignment of the SEC22A sequence (GenBank GENBANK BC007122) with the genomic sequence (GRCh38). ... More on the omim web site
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 612442 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).