V-type proton ATPase subunit G 2 (ATP6V1G2)

The protein contains 118 amino acids for an estimated molecular weight of 13604 Da.

 

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (updated: April 1, 2015)

Protein identification was indicated in the following studies:

  1. Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
  2. Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
  3. Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete		TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.
Protein sequence (FASTA)
Protein coevolution profile (FreeContact)
Multiple Sequence Alignment (Muscle)

Interpro domains
Total structural coverage: 0%
Model score: 0
No model available.

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The reference OMIM entry for this protein is 606853

Atpase, h+ transporting, lysosomal, 13-kd, v1 subunit g, isoform 2; atp6v1g2
Atp6g2

DESCRIPTION

Vacuolar type ATPases are involved in bone resorption, glycosylation in the Golgi, degradation of cellular debris in lysosomes, and the processing of endocytosed receptor-ligand complexes.

CLONING

By sequence analysis of cosmid clones of the G1 region of chromosome 6p21.3, followed by database analysis, Neville and Campbell (1999) identified cDNAs encoding 2 isoforms of ATP6G2. The full-length 118-amino acid protein is 82% similar to the cow protein. The other isoform encodes a 77-amino acid protein. RT-PCR analysis detected expression in lymphocytic but not monocytic or macrophage-like cell lines.

MAPPING

By sequence analysis, Neville and Campbell (1999) mapped the ATP6G2 gene to chromosome 6p21.3, approximately 1 kb telomeric to NFKBIL1 (601022) and centromeric to BAT1 (142560). ... More on the omim web site

Subscribe to this protein entry history

Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated

Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated

March 25, 2017: Additional information
No protein expression data in P. Mayeux work for ATP6V1G2

March 16, 2016: Protein entry updated
Automatic update: OMIM entry 606853 was added.