Receptor expression-enhancing protein 4 (REEP4)
The protein contains 257 amino acids for an estimated molecular weight of 29395 Da.
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is predicted to be membranous by TOPCONS.
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No binding partner found
Biological Process
Cell division
Endoplasmic reticulum tubular network organization
Mitotic nuclear membrane reassembly
Nuclear envelope organization
The reference OMIM entry for this protein is 609349
Receptor expression-enhancing protein 4; reep4
Chromosome 8 open reading frame 20; c8orf20
CLONING
Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical for receptor-ligand recognition. However, mammalian GPCR odorant receptors (ORs), when heterologously expressed in cells, are poorly expressed on the cell surface. By screening for genes that induced cell surface expression of ORs expressed in human embryonic kidney cells, Saito et al. (2004) identified mouse and human REEP1 (609139). They searched databases for homologs of REEP1 and identified several other REEP genes, including REEP4. In situ hybridization of mouse olfactory epithelium revealed that, unlike Reep1, Reep4 was not expressed in olfactory neurons.MAPPING
The International Radiation Hybrid Mapping Consortium mapped the REEP4 gene to chromosome 8. ... More on the omim web site
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 609349 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).