Transmembrane protein 14C (TMEM14C)
The protein contains 112 amino acids for an estimated molecular weight of 11565 Da.
Required for normal heme biosynthesis. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is predicted to be membranous by TOPCONS.
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| Variant | Description |
|---|---|
| dbSNP:rs1045961 | |
| dbSNP:rs1045964 | |
| dbSNP:rs1045967 | |
| dbSNP:rs1045986 |
No binding partner found
Biological Process
Erythrocyte differentiation
Heme biosynthetic process
Mitochondrial transport
Regulation of heme biosynthetic process
Cellular Component
Integral component of membrane
Membrane
Mitochondrial inner membrane
Mitochondrial membrane
Molecular Function
The reference OMIM entry for this protein is 615318
Transmembrane protein 14c; tmem14c
CLONING
Using a computational screen to identify human and mouse genes encoding mitochondrial proteins involved in heme biosynthesis, Nilsson et al. (2009) identified TMEM14C.MAPPING
Gross (2013) mapped the TMEM14C gene to chromosome 6p24.2 based on an alignment of the TMEM14C sequence (GenBank GENBANK AF151028) with the genomic sequence (GRCh37).ANIMAL MODEL
Nilsson et al. (2009) found that targeted knockdown of Tmem14c in zebrafish resulted in profound anemia. ... More on the omim web site
Feb. 23, 2019: Protein entry updated
Automatic update: comparative model was added.
Feb. 23, 2019: Protein entry updated
Automatic update: model status changed
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 615318 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).