Dehydrogenase/reductase SDR family member 7 (DHRS7)
The protein contains 339 amino acids for an estimated molecular weight of 38299 Da.
No function (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs34583017 |
The reference OMIM entry for this protein is 612833
Short-chain dehydrogenase/reductase family, member 7; dhrs7
Sdr family, member 7
Retsdr4
DESCRIPTION
Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000).CLONING
By searching EST databases for SDRs, followed by 3-prime and 5-prime RACE and nested PCR of a human retina cDNA library, Haeseleer and Palczewski (2000) cloned DHRS7, which they called RETSDR4. The deduced 289-amino acid protein has a calculated molecular mass of 32.3 kD. It has all the characteristics of SDRs, including a cofactor-binding Rossman-fold domain and highly conserved motifs in the nucleotide-binding site and active site. Northern blot analysis detected DHRS7 expression in all tissues examined.MAPPING
Hartz (2009) mapped the DHRS7 gene to chromosome 14q23.1 based on an alignment of the DHRS7 sequence (GenBank GENBANK AF126782) with the genomic sequence (build 36.1). ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 612833 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).