Secernin-3 (SCRN3)
The protein contains 424 amino acids for an estimated molecular weight of 48544 Da.
No function (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
- Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
(right-click above to access to more options from the contextual menu)
| Variant | Description |
|---|---|
| dbSNP:rs10497410 | |
| empty | |
| dbSNP:rs6716400 |
No binding partner found
Cellular Component
The reference OMIM entry for this protein is 614967
Secernin 3; scrn3
Ses3
CLONING
By database analysis to identify sequences similar to mouse Scrn1 (614965), Way et al. (2002) identified human SCRN3. The deduced SCRN3 protein contain 243 amino acids.MAPPING
By genomic sequence analysis, Way et al. (2002) mapped the SCRN3 gene to chromosome 2p14-q14.3. Hartz (2012) mapped the SCRN3 gene to chromosome 2q31.1 based on an alignment of the SCRN3 sequence (GenBank GENBANK AK026795) with the genomic sequence (GRCh37). ... More on the omim web site
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 614967 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).