Attractin-like protein 1 (ATRNL1)
The protein contains 1379 amino acids for an estimated molecular weight of 152639 Da.
May play a role in melanocortin signaling pathways that regulate energy homeostasis. (updated: Sept. 12, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is predicted to be membranous by TOPCONS.
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| Variant | Description |
|---|---|
| dbSNP:rs1953758 |
No binding partner found
The reference OMIM entry for this protein is 612869
Attractin-like 1; atrnl1
Kiaa0534
Alp
CLONING
By sequencing clones from a size-fractionated human brain cDNA library, Nagase et al. (1998) cloned ATRNL1, which they designated KIAA0534. By a yeast 2-hybrid screen of a brain cDNA library using the mouse melanocortin-4 receptor (MC4R; 155541) intracellular tail as bait, Haqq et al. (2003) cloned the mouse homolog of ATRNL1. The mouse protein shares 63% sequence identity with the C-terminal part of the mouse attractin gene product (ATRN; 603130), which is required for agouti (600201) signaling through the melanocortin-1 receptor (MC1R; 155555). Northern blot analysis of mouse tissues detected a major 8.5-kb Atrnl1 transcript at high levels in brain, kidney, heart, lung, and liver, and at low levels in spleen, skeletal muscle, and testis. Three minor transcripts were also detected: a 5.5-kb transcript in heart, brain, and kidney, a 5-kb transcript in liver only, and a 5.4-kb transcript in testis only. The tissue expression of Atrnl1 is similar to that of Atrn. RT-PCR analysis showed expression of Atrnl1 from embryonic day 7 throughout development.GENE FUNCTION
Using GST pull-down assays, Haqq et al. (2003) confirmed direct interaction between the C termini of mouse Atrnl1 and Mc4r. Colocalization analyses showed coexpression of Atrnl1 in cells expressing Mc4r in several regions known to be important in the regulation of energy homeostasis by melanocortins, such as the paraventricular nucleus of the hypothalamus and the dorsal motor nucleus of the vagus.MAPPING
By radiation hybrid analysis, Nagase et al. (1998) mapped the KIAA0534 gene to chromosome 10. ... More on the omim web site
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).
Oct. 19, 2018: Protein entry updated
Automatic update: OMIM entry 612869 was added.