39S ribosomal protein L10, mitochondrial (MRPL10)
The protein contains 261 amino acids for an estimated molecular weight of 29283 Da.
No function (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs11538868 | |
| Found in a patient with intellectual disability and ataxia |
Biological Process
Mitochondrial translational elongation
Mitochondrial translational termination
Ribosome biogenesis
Translation
The reference OMIM entry for this protein is 611825
Mitochondrial ribosomal protein l10; mrpl10
Mrpl8
DESCRIPTION
Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation. MRPL10 is 1 of more than 70 protein components of mitochondrial ribosomes that are encoded by the nuclear genome (Kenmochi et al., 2001).CLONING
By searching databases for homologs of rat Mrpl8, Goldschmidt-Reisin et al. (1998) identified mouse and human MRPL10, which they called MRPL8. The deduced 261-amino acid human MRPL10 protein contains a 28-amino acid N-terminal mitochondrial import signal.MAPPING
By radiation hybrid analysis and analysis of an integrated BAC-STS map, Kenmochi et al. (2001) mapped the MRPL10 gene to chromosome 17q21.3. ... More on the omim web site
June 29, 2020: Protein entry updated
Automatic update: OMIM entry 611825 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).