Janus kinase and microtubule-interacting protein 2 (JAKMIP2)
The protein contains 810 amino acids for an estimated molecular weight of 94934 Da.
No function (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs3749736 | |
| a colorectal cancer sample |
No binding partner found
Biological Process
The reference OMIM entry for this protein is 611197
Janus kinase and microtubule-interacting protein 2; jakmip2
Jamip2
Neuroendocrine long coiled-coil protein 1; necc1
Kiaa0555
CLONING
By sequencing clones obtained from a size-fractionated human brain cDNA library, Nagase et al. (1998) cloned JAKMIP2, which they called KIAA0555. Using a differential display method, Cruz-Garcia et al. (2007) identified a nucleotide fragment preferentially expressed in storage melanotropes in frog. Database analysis identified KIAA0555, which the authors called NECC1, as the human homolog. NECC1 encodes a deduced 820-amino acid protein that shares 99% and 88% sequence identity with the mouse and frog homologs, respectively. NECC1 contains 7 predicted coiled-coil domains, which span most of the sequence, and a 19-amino acid C-terminal transmembrane domain. A second isoform of NECC1 results from alternative splicing of exon 20 and lacks the transmembrane domain. By database searching, Cruz-Garcia et al. (2007) also identified a paralog of NECC1, which they designated NECC2 (JAKMIP3; 611198). Fluorescence microscopy localized the NECC1 and NECC2 proteins to the distal compartments of the Golgi complex. By RT-PCR analysis, Cruz-Garcia et al. (2007) found that NECC1 and NECC2 were expressed at highest levels in the central nervous system and in endocrine tissues, including pituitary gland, adrenal gland, and testis. Low expression was found in other tissues such as heart, kidney, thymus, and skeletal muscle. Steindler et al. (2004) stated that the KIAA0555/JAKMIP2 protein shares 58% sequence identity with JAKMIP1/MARLIN1 (611195).GENE FUNCTION
Based on the structure, expression pattern, and sublocalization of the NECC1 and NECC2 proteins, Cruz-Garcia et al. (2007) proposed that they are members of the golgin family of proteins and may be responsible for Golgi structure or function.MAPPING
By radiation hybrid analysis, Nagase et al. (1998) mapped the KIAA0555 gene to chromosome 5. By sequence analysis, Steindler et al. (2004) mapped the KIAA0555 gene to chromosome 5q32. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 611197 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).