Putative beta-actin-like protein 3 (POTEKP)

The protein contains 375 amino acids for an estimated molecular weight of 42016 Da.

 

No function (updated: Sept. 12, 2018)

Protein identification was indicated in the following studies:

  1. D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
  2. Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.

Methods

The following articles were analysed to gather the proteome content of erythrocytes.

The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.

PublicationIdentification 1Uniprot mapping 2Not mapped /
Obsolete		TrEMBLSwiss-Prot
Goodman (2013)2289 (gene list)227853205992269
Lange (2014)123412347281224
Hegedus (2015)2638262202352387
Wilson (2016)165815281702911068
d'Alessandro (2017)18261817201815
Bryk (2017)20902060101081942
Chu (2018)18531804553621387

1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry

The compilation of older studies can be retrieved from the Red Blood Cell Collection database.

The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.

No sequence conservation computed yet.
Protein sequence (FASTA)
Protein coevolution profile (FreeContact)
Multiple Sequence Alignment (Muscle)

Interpro domains
Total structural coverage: 100%
Model score: 0
No model available.

(right-click above to access to more options from the contextual menu)

No binding partner found

The reference OMIM entry for this protein is 611266

Pote ankyrin domain family, member k, pseudogene; potekp
Actin, kappa actin-like protein
Fksg30

CLONING

Using expression profiles of actin isoforms in cancerous and noncancerous hepatoma tissue, Chang et al. (2006) cloned a cDNA encoding kappa-actin, which they also called FKSG30.

GENE FUNCTION

By yeast 2-hybrid assay, Chang et al. (2006) showed that FKSG30 interacted with profilin-1 (PFN1; 176610) and prefoldin-1 (PFDN1; 604897) but not with prefoldin-2, in contrast to beta-actin (ACTB; 102630), which interacted with all 3 proteins tested. By RT-PCR analysis, they compared FKSG30 expression in cancerous and noncancerous hepatoma tissue and suggested that FKSG30 expression may be increased in cancerous tissues. ... More on the omim web site

Subscribe to this protein entry history

Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 611266 was added.

Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).