Fetuin-B (FETUB)
The protein contains 382 amino acids for an estimated molecular weight of 42055 Da.
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity). (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
(right-click above to access to more options from the contextual menu)
| Variant | Description |
|---|---|
| dbSNP:rs34522046 | |
| dbSNP:rs6785067 | |
| dbSNP:rs7999 |
No binding partner found
The reference OMIM entry for this protein is 605954
Fetuin b; fetub
DESCRIPTION
The fetuin family, which includes FETUB, is part of the cystatin superfamily and encompasses a series of tightly related proteins that are synthesized mostly in the liver. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors (147670 and 164860, respectively), and response to systemic inflammation (summary by Olivier et al., 2000).CLONING
In an effort to identify hepatic genes preferentially expressed during acute inflammation, Olivier et al. (1999) identified a partial cDNA encoding rat fetuin B (Fetub). Northern blot analysis detected liver-specific expression of rat Fetub. By searching an EST database using the full-length rat sequence as the probe, Olivier et al. (2000) identified cDNAs encoding human and mouse FETUB. The 382-amino acid human FETUB protein shares sequence and structural similarity with fetuin A (FETUA; 138680). The human, mouse, and rat FETUB proteins share 61% amino acid identity. Northern blot analysis detected a developmentally regulated expression pattern for Fetub in mouse and rat liver that differed between species. In response to inflammatory stimulus, hepatic levels of rat Fetua and Fetub were downregulated.MAPPING
Using ESTs, Olivier et al. (2000) mapped the FETUB gene to 3q27, where the FETUA gene is localized. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 605954 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).