The protein contains 260 amino acids for an estimated molecular weight of 29557 Da.
Reversible hydration of carbon dioxide. (updated: March 4, 2015)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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Variant | Description |
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dbSNP:rs20571 |
The reference OMIM entry for this protein is 114750
Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see 114800. Carbonic anhydrase III is found in high concentration in muscle. It shows relatively poor hydratase and esterase activities compared to the red cell isozymes CA I (114800) and CA II (611492), but is similar in subunit structure (monomer) and molecular mass (28 kD). Heath et al. (1985) explored the use of CA III in conjunction with creatine kinase detection of the carrier state for Duchenne muscular dystrophy. Using a cDNA clone of the CA3 gene in the study of human-rodent hybrids, Edwards et al. (1985, 1986) mapped the gene to chromosome 8 which carries a cluster of CA genes. This was the first assignment of the CA3 locus in any species. Wade et al. (1986) identified a CA3 mRNA transcript from an adult human muscle cDNA library and presented the complete nucleotide sequence of the cDNA clone. Using a panel of human-mouse cell hybrids, they localized the CA3 gene to chromosome 8, thus confirming the work of Edwards et al. (1986). Beechey et al. (1990) mapped the mouse equivalent, Car3, to chromosome 3 and showed, by analysis of an interspecific backcross, that Car3 is 2.4 map units from both Car1 and Car2. No recombinants were found between Car1 and Car2 in 100 backcross offspring. Data on gene frequencies of allelic variants were tabulated by Roychoudhury and Nei (1988). ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 25, 2017: Additional information
No protein expression data in P. Mayeux work for CA3
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 114750 was added.
Jan. 27, 2016: Protein entry updated
Automatic update: model status changed
Jan. 24, 2016: Protein entry updated
Automatic update: model status changed