Fructose-bisphosphate aldolase C (ALDOC)
The protein contains 364 amino acids for an estimated molecular weight of 39456 Da.
No function (updated: March 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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Biological Process
Aging
Animal organ regeneration
Apoptotic process
Canonical glycolysis
Carbohydrate metabolic process
Epithelial cell differentiation
Fructose 1,6-bisphosphate metabolic process
Fructose metabolic process
Gluconeogenesis
Glucose metabolic process
Glycolytic process
Neutrophil degranulation
Pathogenesis
Protein heterotetramerization
Protein homotetramerization
Response to hypoxia
Response to organic cyclic compound
Response to organonitrogen compound
Small molecule metabolic process
The reference OMIM entry for this protein is 103870
Aldolase c, fructose-bisphosphate; aldoc
Aldolase 3
Fructoaldolase c; aldc
CLONING
Rottmann et al. (1987) determined the complete amino acid sequence of aldolase C from recombinant genomic clones. The deduced polypeptide contains 363 amino acids. Aldolase C shares 81% amino acid identity with aldolase A (ALDOA; 103850) and 70% identity with aldolase B (ALDOB; 612724). For additional background information, see 103850.GENE STRUCTURE
Rottmann et al. (1987) determined that the gene structure of ALDOC is the same as that in other aldolase genes in birds and mammals, having 9 exons separated by 8 introns, all in precisely the same positions, with only the intron sizes being different. One of the exons is noncoding. The entire gene is approximately 4 kb long. Buono et al. (1988) presented the complete nucleotide sequence of ALDOC.MAPPING
Tolan et al. (1987) reported the mapping of ALDOC to chromosome 17 by spot-blot analysis of sorted chromosomes. Rocchi et al. (1989) also mapped the gene and narrowed the assignment to 17cen-q21 by in situ hybridization. In addition, they corroborated the assignment of ALDOA to chromosome 16, and of ALDOB to chromosome 9. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 103870 was added.
Jan. 28, 2016: Protein entry updated
Automatic update: model status changed
Jan. 24, 2016: Protein entry updated
Automatic update: model status changed