Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2)
The protein contains 142 amino acids for an estimated molecular weight of 15649 Da.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (updated: March 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs4672 | |
| empty | |
| empty |
The reference OMIM entry for this protein is 186946
Fk506-binding protein 2; fkbp2
Fk506-binding protein, t-cell, 13-kd; fkbp13
For background information on FK506-binding proteins (FKBPs), see FKBP1A (186945).
CLONING
Jin et al. (1991) reported the cloning and subcellular localization of a 13-kD FK506-binding protein (FKBP13), which has a 21-amino acid signal peptide and appears to be membrane-associated. The 120-amino acid mature protein appears to lack a transmembrane domain but a potential endoplasmic reticulum retention sequence (arg-thr-glu-leu) is found at its C terminus. FKBP13 shares 51% nucleotide sequence identity and 43% amino acid sequence identity with FKBP12 (FKBP1; 186945), the predominant FK506- and rapamycin-binding protein in human T cells. Jin et al. (1991) noted that conserved residues that comprise the drug binding site and rotamase active site of FKBP12 are completely conserved in FKBP13.GENE STRUCTURE
DiLella et al. (1992) found that the FKBP2 gene is 3 kb long and contains 6 exons.MAPPING
By fluorescence in situ hybridization, DiLella et al. (1992) mapped the FKBP2 gene to 11q13.1-q13.3. Courseaux et al. (1996) used a combination of methods to refine maps of the approximately 5-Mb region of 11q13 that includes MEN1 (131100). They proposed the following gene order: cen--PGA--FTH1--UGB--AHNAK--ROM1--MDU1--CHRM1--COX8--EMK1--FKBP2--PLCB3--[PYGM, ZFM1]--FAU--CAPN1--[MLK3, RELA]--FOSL1--SEA--CFL1--tel. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 186946 was added.
Jan. 28, 2016: Protein entry updated
Automatic update: model status changed
Jan. 25, 2016: Protein entry updated
Automatic update: model status changed