Serum amyloid A-4 protein (SAA4)
The protein contains 130 amino acids for an estimated molecular weight of 14747 Da.
Major acute phase reactant. (updated: June 17, 2020)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| Confirmed at protein level |
No binding partner found
The reference OMIM entry for this protein is 104752
Serum amyloid a4; saa4
Amyloid a, serum, 4
Serum amyloid a4, constitutive
DESCRIPTION
The acute phase reactant serum amyloid A (SAA) is a polymorphic apolipoprotein encoded by a family of highly homologous and closely linked genes (summary by Steel et al., 1993). For background information on SAA, see SAA1 (104750).CLONING
Studying protein and cDNA, Whitehead et al. (1992) identified a member of the serum amyloid A protein superfamily, designated SAA4, as constitutive apolipoprotein of high density lipoprotein. Watson et al. (1992) analyzed the derived protein structure of SAA4.GENE STRUCTURE
Watson et al. (1992) analyzed the structure of the SAA4 gene. Steel et al. (1993) determined that the SAA4 gene shares the same 5-prime to 3-prime orientation and has the characteristic 4-exon structure of the other members of the SAA superfamily.MAPPING
Steel et al. (1993) demonstrated that the SAA4 gene is located 9 kb downstream of the SAA2 gene (104751) on chromosome 11. By fluorescence in situ hybridization using a cosmid probe carrying the SAA2 and SAA4 genes, Sellar et al. (1994) localized these genes to 11p15.1. De Beer et al. (1996) found that in the mouse the Saa4 gene is linked to the serum amyloid A gene family on chromosome 7. ... More on the omim web site
June 29, 2020: Protein entry updated
Automatic update: Entry updated from uniprot information.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
June 20, 2017: Protein entry updated
Automatic update: comparative model was added.
March 25, 2017: Additional information
No protein expression data in P. Mayeux work for SAA4
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 104752 was added.
Feb. 25, 2016: Protein entry updated
Automatic update: model status changed
Feb. 24, 2016: Protein entry updated
Automatic update: model status changed
Jan. 25, 2016: Protein entry updated
Automatic update: model status changed