The protein contains 146 amino acids for an estimated molecular weight of 16445 Da.
No function (updated: April 1, 2015)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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The reference OMIM entry for this protein is 603675
The mammalian ribosome is composed of 4 RNA species (see 180450) and approximately 80 different proteins. To identify genes that are differentially expressed in a poorly differentiated human pancreatic tumor cell line (Panc-1) compared to a well-differentiated pancreatic tumor cell line (CD11), Batra et al. (1991) screened a Panc-1 cDNA library by differential hybridization using Panc-1 and CD11 cDNAs. They isolated a cDNA encoding ribosomal protein S16 (RPS16). On Northern blots, the RPS16 cDNA hybridized to a 650-bp transcript showing 30-fold higher expression in Panc-1 cells than in CD11 cells. The RPS16 transcript was not overexpressed in the other 13 pancreatic tumor cell lines examined or in 2 breast cancer cell lines, 2 colon cancer cell lines, or normal tissues. Southern blot analysis showed a 20-fold amplification of the RPS16 gene only in the Panc-1 cell line. The deduced 146-amino acid RPS16 protein is identical to rat Rps16. By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi et al. (1998) mapped the human RPS16 gene to 19q. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 15, 2016: Protein entry updated
Automatic update: OMIM entry 603675 was added.