Rab-like protein 6 (RABL6)
The protein contains 729 amino acids for an estimated molecular weight of 79549 Da.
May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A. (updated: March 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Wilson and co-workers. (2016) Comparison of the Proteome of Adult and Cord Erythroid Cells, and Changes in the Proteome Following Reticulocyte Maturation. Mol Cell Proteomics. 15(6), 1938-1946.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| dbSNP:rs2811741 |
The reference OMIM entry for this protein is 610615
Partner of arf
Parf
Chromosome 9 open reading frame 86; c9orf86
CLONING
Using the p19(Arf) isoform of mouse Cdkn2a (600160) as bait in a yeast 2-hybrid screen of a mouse embryonic fibroblast cDNA library, followed by RT-PCR of human brain cDNA, Tompkins et al. (2006) cloned mouse and human PARF. The deduced 729-amino acid human protein has an N-terminal GTP-binding domain, followed by a RAB (see 179508)-like domain, 2 proline-rich sequences, and a C-terminal nuclear localization signal.GENE FUNCTION
Using in vitro and in vivo binding assays, including reciprocal immunoprecipitation assays, Tompkins et al. (2006) confirmed that PARF bound p19(ARF), but not the p16(INK4A) isoform of CDKN2A. PARF appeared to shuttle in and out of the nucleus of transfected human cells. Knockdown of PARF by RNA interference enhanced the rate of cell proliferation and reduced the growth inhibitory activity of p19(ARF).MAPPING
The International Radiation Hybrid Mapping Consortium mapped the TBRG1 gene to chromosome 11 (TMAP STS-T95820). ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 610615 was added.