Ubiquitin-like protein 7 (UBL7)
The protein contains 380 amino acids for an estimated molecular weight of 40510 Da.
No function (updated: March 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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The reference OMIM entry for this protein is 609748
Ubiquitin-like 7; ubl7
CLONING
From large-scale screening of a bone marrow stromal cell (BMSC) cDNA library, Liu et al. (2003) identified UBL7, a novel cDNA encoding a deduced 380-amino acid protein with a predicted molecular mass of 40.6 kD. The protein, which they designated BMSC-UbP, contains a UBQ domain at its N terminus and a ubiquitin-associated domain at its C terminus. It shares moderate homology with several ubiquitin-like proteins including UBQLN1 (605046) and UBQLN2 (300264). Northern blot analysis revealed an approximately 1.3-kb UBL7 transcript in all human tissues tested. RT-PCR detected expression of UBL7 in several tumor cell lines.GENE FUNCTION
Liu et al. (2003) found that expression of UBL7 was significantly down-regulated in PMA-stimulated BMSC but was not obviously changed in LPS-stimulated BMSC. UBL7 expression was up-regulated in LPS-stimulated acute promyelocytic HL60 cells but remained unchanged in PMA-stimulated HL60 cells. Liu et al. (2003) suggested that UBL7 may play a role in the regulation of BMSC function or cell differentiation through an evocator- and cell-specific pattern.MAPPING
By sequence analysis, Liu et al. (2003) mapped the UCL7 gene to chromosome 15q22.3-q23. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 609748 was added.