The protein contains 666 amino acids for an estimated molecular weight of 74824 Da.
Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. (updated: Jan. 7, 2015)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology, is annotated as membranous in UniProt, is predicted to be membranous by TOPCONS.
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The reference OMIM entry for this protein is 607961
The reference OMIM entry for this protein is 614745
A number sign (#) is used with this entry because the John Milton Hagen (JMH) blood group system is based, at least partly, on variation in the gene encoding semaphorin-7A (SEMA7A; 607961) on chromosome 15q22.2-q23.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 607961 was added.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 614745 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 607961 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 614745 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 607961 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 614745 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 614745 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 607961 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 607961 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Sept. 23, 2019: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Sept. 23, 2019: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Aug. 21, 2019: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Aug. 21, 2019: Protein entry updated
Automatic update: OMIM entry 614745 was added.
July 5, 2019: Protein entry updated
Automatic update: OMIM entry 607961 was added.
July 5, 2019: Protein entry updated
Automatic update: OMIM entry 614745 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 614745 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 607961 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 607961 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Nov. 17, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Nov. 17, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Oct. 2, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Oct. 2, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
July 7, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
July 7, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
July 3, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
July 3, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 607961 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 614745 was added.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 607961 was added.
Jan. 28, 2016: Protein entry updated
Automatic update: model status changed
Jan. 25, 2016: Protein entry updated
Automatic update: model status changed