Exocyst complex component 3 (EXOC3)
The protein contains 756 amino acids for an estimated molecular weight of 86845 Da.
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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The reference OMIM entry for this protein is 608186
Exocyst complex component 3; exoc3
Sec6, s. cerevisiae, homolog of; sec6
DESCRIPTION
SEC6 is part of a multiprotein complex involved in vesicle trafficking at neural synapses and vesicle targeting in polarized epithelial cells (Hsu et al., 1996; Grindstaff et al., 1998).GENE FUNCTION
Hsu et al. (1996) purified rat brain Sec6, which was present in a 743-kD complex with Sec8 (608185) and 6 other proteins. The complex was broadly expressed in rat brain and displayed a plasma membrane localization in nerve terminals. The Sec6/Sec8 complex coimmunoprecipitated with syntaxin (see 186590). Hsu et al. (1996) concluded that the rat Sec6/Sec8 complex is involved in neurotransmitter release via interactions with the core vesicle docking and fusion apparatus. Grindstaff et al. (1998) found that the Sec6/Sec8 complex was a component of a cytosolic 17S complex in nonpolarized canine kidney epithelial cells. Upon initiation of calcium-dependent cell-cell adhesion, about 70% of the complex was recruited to sites of cell-cell contact. Grindstaff et al. (1998) concluded that lateral membrane recruitment of the Sec6/Sec8 complex is a consequence of cell-cell adhesion and is essential for the development of epithelial cell surface polarity.MAPPING
Gross (2011) mapped the EXOC3 gene to chromosome 5p15.33 based on an alignment of the EXOC3 sequence (GenBank GENBANK BC064569) with the genomic sequence (GRCh37). ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 608186 was added.
Feb. 23, 2019: Protein entry updated
Automatic update: model status changed
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).