Serine/threonine-protein kinase 10 (STK10)
The protein contains 968 amino acids for an estimated molecular weight of 112135 Da.
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. (updated: March 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology, is annotated as membranous in UniProt.
(right-click above to access to more options from the contextual menu)
No binding partner found
Biological Process
Activation of protein kinase activity
Cell cycle
Intracellular signal transduction
Lymphocyte aggregation
Neutrophil degranulation
Protein autophosphorylation
Protein phosphorylation
Regulation of apoptotic process
Regulation of lymphocyte migration
Regulation of mitotic cell cycle
Signal transduction by protein phosphorylation
Stress-activated protein kinase signaling cascade
The reference OMIM entry for this protein is 273300
Testicular germ cell tumor; tgct
Male germ cell tumor; mgct seminoma, included
Nonseminomatous germ cell tumors, included
Teratoma, testicular, included
Embryonal cell carcinoma, included
Endodermal sinus tumor, included
Spermatocytic sem
A number sign (#) is used with this entry because testicular germ cell tumors have been associated with somatic mutation in several genes; see
MOLECULAR GENETICS
.DESCRIPTION
Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in western European populations. The incidence of TGCT rose dramatically during the 20th century. Known risk factors for TGCT include a history of undescended testis (UDT), testicular dysgenesis, infertility, previously diagnosed TGCT, and a family history of the disease. Brothers of men with TGCT have an 8- to 10-fold risk of developing TGCT, whereas the relative risk to fathers and sons is 4-fold. This familial relative risk is much higher than that for most other types of cancer (summary by Rapley et al., 2000). - Genetic Heterogeneity of Testicular Germ Cell Tumors A locus for testicular germ cell tumors (TGCT1; 300228) has been identified on chromosome Xq27.CLINICAL FEATURES
Hutter et al. (1967) reviewed the reports of testicular tumors in brothers and in twins and reported affected brothers. Gustavson et al. (1975) reported bilateral testicular teratoma in 2 infant brothers with XXY Klinefelter syndrome. One of them also had hydrocephalus due to stenosis of the aqueduct of Sylvius. Familial occurrence of the Klinefelter syndrome is rare. The association of the Klinefelter syndrome and testicular teratoma may be more than coincidental because they have been observed together in other cases and many testicular teratoma are both X-chromatin and Y-chromatin positive suggesting that they are XXY. Raghavan et al. (1980) reported a father who had sequential bilateral seminomas and a son who had embryonal cell carcinoma and seminoma. The authors reviewed 5 other reports of testicular tumors in father and son, as well as 7 reports of concordant monozygotic twin pairs and 11 reports of nontwin brothers. The report of Raghavan et al. (1980) illustrates the dominant inheritance of hereditary tumors and their bilaterality (e.g., acoustic neuroma, retinoblastoma, pheochromocytoma, etc.). The sons (and other first-degree relatives) of men with bilateral tumors may be at particular risk. Shinohara et al. (1980) reported mature testicular teratoma in 2 first cousins. Furthermore, the common grandparents were consanguineous, being related as first cousins. The parent (i.e., the parent involved in the consanguinity) of the teratoma-carrying boys was the mother in one case and the father in the other. In a 10-member sibship in a Spanish-American family, DiBella (1983) described testicular neoplasm in 3 brothers, benign ovarian neoplasms in 2 sisters, suspected benign tumors of the uterus in 2 additional sisters, and a suspected testicular mass in a fourth brother. Lynch et al. (1985) described the infantile form of embryonal carcinoma of the testis in a 5-year-old boy and in a 23-year-old man who was the maternal half brother of his mother. Copeland et al. (1986) reported testicular embryonal carcinoma in 2 brothers and a first cousin. Von der Maase et al. (1986) found carcinoma in situ in the contralateral testis in 27 of 500 patients (5.4%) with unilateral testicular germ cell cancer. The estimated risk of developing invasive growth from the contralateral testicular cancer was 40% within 3 years and 50% within 5 years. None of the 473 patients without carcinoma in situ detected by screening biopsy developed contralateral testicular can ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 273300 was added.