Trafficking protein particle complex subunit 1 (TRAPPC1)
The protein contains 145 amino acids for an estimated molecular weight of 16832 Da.
May play a role in vesicular transport from endoplasmic reticulum to Golgi. (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| a melanoma |
Biological Process
COPII vesicle coating
Endoplasmic reticulum to Golgi vesicle-mediated transport
Neutrophil degranulation
The reference OMIM entry for this protein is 610969
Trafficking protein particle complex, subunit 1; trappc1
Bet5, s. cerevisiae, homolog of
Melanoma ubiquitous mutated 2; mum2
CLONING
By screening a PAC library with a cDNA clone isolated from a melanoma cell line, followed by 5-prime RACE, Chiari et al. (1999) obtained TRAPPC1, which they called MUM2. The deduced 145-amino acid protein is homologous to yeast Bet5. Northern blot analysis detected TRAPPC1 at 0.8 kb.GENE FUNCTION
Chiari et al. (1999) noted that yeast Bet5 is implicated in vesicular transport of proteins from the endoplasmic reticulum to the Golgi. They found that wildtype TRAPPC1 could complement Bet5 function in yeast with a disrupted Bet5 gene. They concluded that the function of TRAPPC1 is conserved in eukaryotic cells and that it is involved in vesicular transport of proteins.GENE STRUCTURE
Chiari et al. (1999) determined that the TRAPPC1 gene contains 5 exons.MAPPING
By radiation hybrid analysis, Chiari et al. (1999) mapped the TRAPPC1 gene to chromosome 17p13. ... More on the omim web site
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 610969 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).