Protein Z-dependent protease inhibitor (SERPINA10)
The protein contains 444 amino acids for an estimated molecular weight of 50707 Da.
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors. (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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No binding partner found
The reference OMIM entry for this protein is 602455
Regeneration-associated serpin-1
Rasp1
The mammalian liver has an extraordinary capacity for regeneration. In the rat, the liver regenerates the most of its original mass within several days following hepatectomy; regeneration is virtually complete by 2 weeks after surgery. Studies of gene expression after hepatectomy have focused on events occurring the first few hours after surgery. For example, the augmenter of liver regeneration ALR (600924) was isolated in this way. New et al. (1996) isolated a gene encoding a plasma protein by constructing and screening a cDNA library with RNA isolated from liver at 48 hours after 70 to 90% hepatectomy. New et al. (1996) stated that the expression of acute phase inflammatory proteins should be substantially diminished, thereby reducing the 'background' and facilitating the identification of genes associated with regeneration. They identified several clones that were upregulated in the regenerating liver. They isolated 1 clone, termed 'regeneration-associated serpin-1' (RASP1), that was expressed in normal liver but was upregulated approximately 3- to 4-fold by 48 hours after hepatectomy. DNA sequence analysis showed that the RASP1 gene encodes a novel 436-amino acid secreted protein. Moderate homology was found with several members of the serpin family of serine-protease inhibitors. The 1.7-kb RASP1 mRNA was highly expressed in rat liver, but not in brain, heart, kidney, lung, testis, or spleen. It was found in normal and hepatectomy rat plasma. ... More on the omim web site
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 602455 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).