The protein contains 1744 amino acids for an estimated molecular weight of 192785 Da.
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.', 'Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. (updated: April 1, 2015)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is annotated as membranous in Gene Ontology.
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The reference OMIM entry for this protein is 120790
A number sign (#) is used with this entry because of evidence that the mutation resides in the gene for the C1 inhibitor (C1NH; 606860).
The reference OMIM entry for this protein is 614374
A number sign (#) is used with this entry because the Chido/Rodgers blood group system is based on variation in 2 closely linked genes, C4A (120810) and C4B (120820).
The reference OMIM entry for this protein is 120810
The reference OMIM entry for this protein is 152700
A number sign (#) is used with this entry because of evidence that multiple genes are involved in the causation of systemic lupus erythematosus.
The reference OMIM entry for this protein is 614380
A number sign (#) is used with this entry because C4A deficiency is caused by mutation in the C4A gene (120810).
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 120790 was added.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 120810 was added.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 152700 was added.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 614374 was added.
July 2, 2021: Protein entry updated
Automatic update: OMIM entry 614380 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 120790 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 120810 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 152700 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 614374 was added.
April 11, 2021: Protein entry updated
Automatic update: OMIM entry 614380 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 120790 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 120810 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 152700 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 614374 was added.
Feb. 17, 2021: Protein entry updated
Automatic update: OMIM entry 614380 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 120790 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 120810 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 152700 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 614374 was added.
Oct. 21, 2020: Protein entry updated
Automatic update: OMIM entry 614380 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 120790 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 120810 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 152700 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 614374 was added.
Aug. 25, 2020: Protein entry updated
Automatic update: OMIM entry 614380 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 614374 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 614380 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 120790 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 120810 was added.
June 30, 2020: Protein entry updated
Automatic update: OMIM entry 152700 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 152700 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 614374 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 614380 was added.
April 26, 2020: Protein entry updated
Automatic update: OMIM entry 120810 was added.
April 25, 2020: Protein entry updated
Automatic update: OMIM entry 120790 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 614380 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 120790 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 120810 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 152700 was added.
March 4, 2020: Protein entry updated
Automatic update: OMIM entry 614374 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 614380 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 120790 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 120810 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 152700 was added.
Jan. 23, 2020: Protein entry updated
Automatic update: OMIM entry 614374 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 120790 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 120810 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 152700 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 614374 was added.
Dec. 3, 2019: Protein entry updated
Automatic update: OMIM entry 614380 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 152700 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 614374 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 614380 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 120790 was added.
Oct. 28, 2019: Protein entry updated
Automatic update: OMIM entry 120810 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 120790 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 120810 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 152700 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 614374 was added.
June 7, 2019: Protein entry updated
Automatic update: OMIM entry 614380 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 614374 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 614380 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 120790 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 120810 was added.
May 12, 2019: Protein entry updated
Automatic update: OMIM entry 152700 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 120790 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 120810 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 152700 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 614374 was added.
July 6, 2018: Protein entry updated
Automatic update: OMIM entry 614380 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 120790 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 120810 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 152700 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 614374 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 614380 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 120790 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 120810 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 152700 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 614374 was added.
July 5, 2018: Protein entry updated
Automatic update: OMIM entry 614380 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 120790 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 120810 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 152700 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 614374 was added.
July 4, 2018: Protein entry updated
Automatic update: OMIM entry 614380 was added.
July 2, 2018: Protein entry updated
Automatic update: OMIM entry 120790 was added.
July 2, 2018: Protein entry updated
Automatic update: OMIM entry 120810 was added.
July 2, 2018: Protein entry updated
Automatic update: OMIM entry 152700 was added.
July 2, 2018: Protein entry updated
Automatic update: OMIM entry 614374 was added.
July 2, 2018: Protein entry updated
Automatic update: OMIM entry 614380 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 120790 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 120810 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 152700 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 614374 was added.
May 27, 2018: Protein entry updated
Automatic update: OMIM entry 614380 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 120810 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 152700 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 614374 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 614380 was added.
April 27, 2018: Protein entry updated
Automatic update: OMIM entry 120790 was added.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 25, 2017: Additional information
No protein expression data in P. Mayeux work for C4A
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 120790 was added.