The protein contains 456 amino acids for an estimated molecular weight of 52904 Da.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (updated: Nov. 22, 2017)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
(right-click above to access to more options from the contextual menu)
Variant | Description |
---|---|
dbSNP:rs2230680 |
The reference OMIM entry for this protein is 604450
The 26S proteasome is responsible for the ATP-dependent degradation of a variety of cellular proteins. Selective breakdown of these proteins is mediated by the ubiquitin pathway. The 26S proteasome is a 2,000-kD protein complex composed of the 20S proteasome, which is the catalytic subcomplex, and PA700, which is the regulatory subcomplex. The approximately 700-kD PA700 complex consists of approximately 20 heterogeneous proteins ranging from 25 to 112 kD. These subunits can be divided into 2 classes, those that are members of the AAA (ATPases associated with various cellular activities) family and those that are not. Saito et al. (1997) sequenced peptides from the p55 subunit of the bovine PA700 complex. They identified a human EST encoding a homologous protein and used this EST to isolate hepatoblastoma HepG2 cell cDNAs encoding human p55, also called PSMD12. The deduced 456-amino acid PSMD12 protein has a calculated molecular mass of 52,903 Da. The authors identified a putative S. cerevisiae homolog, which they named NAS5, that shares 41.1% amino acid sequence identity with PSMD12. Disruption of the NAS5 gene resulted in lethality. ... More on the omim web site
Feb. 5, 2018: Protein entry updated
Automatic update: Entry updated from uniprot information.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 3, 2017: Protein entry updated
Automatic update: OMIM entry 604450 was added.