The protein contains 201 amino acids for an estimated molecular weight of 22836 Da.
Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). (updated: Feb. 10, 2021)
Protein identification was indicated in the following studies:
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
---|---|---|---|---|---|
Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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The reference OMIM entry for this protein is 602175
The proteasome is responsible for degradation of short lived and misfolded cytosolic and nuclear proteins in the cell. It consists of a complex of proteins that form a 20S core particle in both prokaryotes and eukaryotes. The 20S proteasome is composed of 7 alpha and 7 beta subunits that dimerize to form an alpha(7)beta(7)beta(7)alpha(7) structure. Subunits are designated alpha or beta depending on their homology to the Thermoplasma acidophilus proteasome in which the beta subunits are catalytically active. The 20S core complex associates with regulatory proteins that function as proteasome activators in vivo. One pathway of activation uses a 19S complex that is involved in the ubiquitin (191339) pathway of protein breakdown. The PA28 complex is an alternative proteasome activator that does not employ the use of ubiquitin. The complex is composed of 2 homologous subunits called alpha and beta, which form a hexameric ring. PA28 appears to be involved in the presentation of endogenous antigens by MHC class I molecules. The PA28 complex is expressed constitutively in antigen-presenting cells, and its expression is upregulated by interferon gamma (147570). Many of the genes involved in class I antigen presentation are encoded within the MHC, including the 2 proteasome subunits PSMB9 (177045), also known as LMP2, and PSMB8 (177046), also known as LMP7. McCusker et al. (1997) completed the mapping of the human proteasome beta-type genes: by fluorescence in situ hybridization they mapped the PSMB2 gene to 1p34.2, the PSMB3 gene (602176) to 2q35, and the PSMB4 gene (602177) to 1q21. They also showed that the genes encoding the alpha (600654) and beta (602161) subunits of the PA28 complex are closely linked on 14q11.2, within 1 Mb of the beta proteasome locus PSMB5 (600306). Thus, with the exception of the genes encoding the PSMB9 and PSMB8 subunits, the beta genes are not closely linked in the human genome. PSMB2 and PSMB4 map to regions of chromosome 1 that are proposed to be paralogous to regions of the human genome where other beta proteasome genes map: chromosome 6, containing the major histocompatibility complex, and chromosome 9. ... More on the omim web site
Feb. 16, 2021: Protein entry updated
Automatic update: Entry updated from uniprot information.
Feb. 10, 2018: Protein entry updated
Automatic update: Entry updated from uniprot information.
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 602175 was added.