Alexandre G. de Brevern's publications

Year 2000

  1. de Brevern A.G. , Etchebest C., Hazout S.
    Bayesian probabilistic approach for predicting backbone structures in terms of protein blocks
    Proteins (2000) 41, 271-287

    Using an unsupervised cluster analyser, we have identified a local structural alphabet composed of 16 folding patterns of five consecutive Cα ("protein blocks"). The dependence that exists between successive blocks is explicitly taken into account. A Bayesian approach based on the relation protein block-amino acid propensity is used for prediction and leads to a success rate close to 35 %. Sharing sequence windows associated with certain blocks into "sequence families" improves the prediction accuracy by 6 %. This prediction accuracy exceeds 75 % when keeping the first four predicted protein blocks at each site of the protein.
    matrices, color figure of figure 2 color figure 2.

Alexandre G. de Brevern
Last Modification : March 2024
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