49. de Brevern A.G.
    3D-structural models of transmembrane proteins
    Membrane protein structure determination: from structure to function Methods in Molecular Biology collection (2010) 654:387-401
    Lacapère J.J. ed., Humana Press Inc. Totowa, NJ, USA.
    
    Transmembrane proteins are macromolecules implicated in major biological process and diseases. Due to their specific neighborhood, few transmembrane protein structures are nowadays available. The building of structural models of transmembrane proteins is a major research area. Due to the lack of available 3D structures, automatic homology modeling is not an efficient way to propose pertinent structural models. Hence, most of the structural models of transmembrane proteins are done through a more complex protocol. This latter comprises the use of secondary structure prediction to complete the comparative modeling process. Then, refinement and assessment steps are performed go often to a novel comparative modeling process. Nowadays, it is also possible to take attention to the helix – helix and helix – lipid interactions, and, to build even quaternary structures. In all cases, the taking into account of experimental data is the most important factor to proceed to correct structural models.
    
    preprint manuscript.

Alexandre G. de Brevern
Last Modification : March 2024