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Human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395

Organism: Homo sapiens
Model: Experimental
Representation: Atomistic
Type: α-helical

Pfam Acc: PF00002
PDB ID: 4K5Y


Membrane assignment:

Output PDB file Download

Hydrophobic thickness = 21.3 Å

Number of TM segments = 7

Sequence positions:
A: 121-142|153-167|198-212|225-239|275-288|316-330|339-363

Tilt angles:
A - Segment: 121-142 - Tilt: 53.7°
A - Segment: 153-167 - Tilt: 40.0°
A - Segment: 198-212 - Tilt: 30.2°
A - Segment: 225-239 - Tilt: 32.4°
A - Segment: 275-288 - Tilt: 25.5°
A - Segment: 316-330 - Tilt: 24.3°
A - Segment: 339-363 - Tilt: 59.3°


Structural assessment:

MAIDEN score = -51.8313
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.


Scores for all residue pairs Download




[creation date: Sep-08-2016]