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Human OX2 orexin receptor bound to the insomnia drug Suvorexant

Organism: Homo sapiens
Model: Experimental
Representation: Coarse-grained
Type: α-helical

Pfam Acc: PF00001
PDB ID: 4S0V


Membrane assignment:

Output PDB file Download

Hydrophobic thickness = 20.4 Å

Number of TM segments = 7

Sequence positions:
A: 14-27|44-59|76-97|123-138|163-183|403-417|449-465

Tilt angles:
A - Segment: 14-27 - Tilt: 5.7°
A - Segment: 44-59 - Tilt: 26.6°
A - Segment: 76-97 - Tilt: 56.9°
A - Segment: 123-138 - Tilt: 30.6°
A - Segment: 163-183 - Tilt: 50.4°
A - Segment: 403-417 - Tilt: 40.3°
A - Segment: 449-465 - Tilt: 38.4°


Structural assessment:

MAIDEN score = -39.6222
The MAIDEN score is aimed at assessing the relative quality, i.e. ranking several models (the lower the score, the better the model). It comes here with a color code (red > yellow > green > blue), which is derived from a z-score calculation and indicates the absolute quality.


Scores for all residue pairs Download




[creation date: Sep-08-2016]