Golgi-associated plant pathogenesis-related protein 1 (GLIPR2)
The protein contains 154 amino acids for an estimated molecular weight of 17218 Da.
No function (updated: Feb. 4, 2015)
Protein identification was indicated in the following studies:
- Goodman and co-workers. (2013) The proteomics and interactomics of human erythrocytes. Exp Biol Med (Maywood) 238(5), 509-518.
- Lange and co-workers. (2014) Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteome. J Proteome Res. 13(4), 2028-2044.
- Hegedűs and co-workers. (2015) Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications. Database (Oxford) 1-8.
- Wilson and co-workers. (2016) Comparison of the Proteome of Adult and Cord Erythroid Cells, and Changes in the Proteome Following Reticulocyte Maturation. Mol Cell Proteomics. 15(6), 1938-1946.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
- Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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No binding partner found
The reference OMIM entry for this protein is 607141
Glioma pathogenesis-related protein 2; glipr2
Golgi-associated pr1 protein; gapr1
Chromosome 9 open reading frame 19; c9orf19
CLONING
Using a positional cloning strategy, Eisenberg et al. (2002) identified a novel transcript in the critical region for IBM2 (600737) on chromosome 9p13-p12. They cloned the full-length cDNA, designated C9ORF19, from a human placenta cDNA library. C9ORF19 encodes a deduced 154-amino acid protein with a calculated molecular mass of 17.2 kD. Northern blot analysis detected a 1.9-kb transcript in most adult tissues tested, with highest expression in lung and peripheral leukocytes and minor expression in liver and kidney.GENE STRUCTURE
Eisenberg et al. (2002) determined that the GLIPR2 gene contains 5 exons and spans more than 27 kb.GENE FUNCTION
Shoji-Kawata et al. (2013) showed that a peptide, Tat-beclin-1, derived from a region of the autophagy protein beclin-1 (604378), which binds HIV-1 Nef, is a potent inducer of autophagy, and interacts with a negative regulator of autophagy, GAPR1 (also called GLIPR2). Tat-beclin-1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, including HIV-1, in vitro, and reduces mortality in mice infected with chikungunya or West Nile virus. Shoji-Kawata et al. (2013) concluded that, through the characterization of a domain of beclin-1 that interacts with HIV-1 Nef, they have developed an autophagy-inducing peptide that has potential efficacy in the treatment of human diseases.MAPPING
By sequence analysis, Eisenberg et al. (2002) mapped the GLIPR2 gene to chromosome 9p13-p12.MOLECULAR GENETICS
By mutation analysis in patients with IBM2, Eisenberg et al. (2002) excluded C9ORF19 as the disease-causing gene. ... More on the omim web site
Feb. 2, 2018: Protein entry updated
Automatic update: Uniprot description updated
Dec. 19, 2017: Protein entry updated
Automatic update: Uniprot description updated
Nov. 23, 2017: Protein entry updated
Automatic update: Uniprot description updated
March 16, 2016: Protein entry updated
Automatic update: OMIM entry 607141 was added.
Jan. 28, 2016: Protein entry updated
Automatic update: model status changed
Jan. 24, 2016: Protein entry updated
Automatic update: model status changed