60S ribosomal protein L6 (RPL6)
The protein contains 288 amino acids for an estimated molecular weight of 32728 Da.
Component of the large ribosomal subunit.', '(Microbial infection) Specifically binds to domain C of the Tax-responsive enhancer element in the long terminal repeat of HTLV-I (PubMed:8457378). (updated: Oct. 10, 2018)
Protein identification was indicated in the following studies:
- Wilson and co-workers. (2016) Comparison of the Proteome of Adult and Cord Erythroid Cells, and Changes in the Proteome Following Reticulocyte Maturation. Mol Cell Proteomics. 15(6), 1938-1946.
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
- Chu and co-workers. (2018) Quantitative mass spectrometry of human reticulocytes reveal proteome-wide modifications during maturation. Br J Haematol. 180(1), 118-133.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
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| Variant | Description |
|---|---|
| a colorectal cancer sample; somatic mutation | |
| dbSNP:rs17851813 | |
| dbSNP:rs16942044 |
Biological Process
Cytoplasmic translation
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Regulation of transcription, DNA-templated
Ribosomal large subunit assembly
RRNA processing
SRP-dependent cotranslational protein targeting to membrane
Translation
Translational initiation
Viral transcription
The reference OMIM entry for this protein is 603703
Ribosomal protein l6; rpl6
The mammalian ribosome is composed of 4 RNA species (see 180450) and approximately 80 different proteins. Zaman (1993) isolated a human lung cancer cell line cDNA encoding ribosomal protein L6 (RPL6). The deduced RPL6 protein has 288 amino acids, of which 24% are basic. Morita et al. (1993) isolated a human Jurkat cell cDNA encoding RPL6, which they named TAXREB107. Immunoblot analysis using antibodies against RPL6 detected a 34-kD protein in Jurkat cells. The RPL6 protein can bind to the tax-responsive enhancer element of human T-cell leukemia virus type 1 (HTLV-1). By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi et al. (1998) mapped the RPL6 gene to 12q. ... More on the omim web site
June 29, 2020: Protein entry updated
Automatic update: OMIM entry 603703 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).