Ergosterol biosynthetic protein 28 homolog (ERG28)
The protein contains 140 amino acids for an estimated molecular weight of 15864 Da.
No function (updated: Feb. 26, 2020)
Protein identification was indicated in the following studies:
- Bryk and co-workers. (2017) Quantitative Analysis of Human Red Blood Cell Proteome. J Proteome Res. 16(8), 2752-2761.
- D'Alessandro and co-workers. (2017) Red blood cell proteomics update: is there more to discover? Blood Transfus. 15(2), 182-187.
Methods
The following articles were analysed to gather the proteome content of erythrocytes.
The gene or protein list provided in the studies were processed using the ID mapping API of Uniprot in September 2018. The number of proteins identified and mapped without ambiguity in these studies is indicated below.
Only Swiss-Prot entries (reviewed) were considered for protein evidence assignation.
| Publication | Identification 1 | Uniprot mapping 2 | Not mapped / Obsolete | TrEMBL | Swiss-Prot |
|---|---|---|---|---|---|
| Goodman (2013) | 2289 (gene list) | 2278 | 53 | 20599 | 2269 |
| Lange (2014) | 1234 | 1234 | 7 | 28 | 1224 |
| Hegedus (2015) | 2638 | 2622 | 0 | 235 | 2387 |
| Wilson (2016) | 1658 | 1528 | 170 | 291 | 1068 |
| d'Alessandro (2017) | 1826 | 1817 | 2 | 0 | 1815 |
| Bryk (2017) | 2090 | 2060 | 10 | 108 | 1942 |
| Chu (2018) | 1853 | 1804 | 55 | 362 | 1387 |
1 as available in the article and/or in supplementary material
2 uniprot mapping returns all protein isoforms as one entry
The compilation of older studies can be retrieved from the Red Blood Cell Collection database.
The data and differentiation stages presented below come from the proteomic study and analysis performed by our partners of the GReX consortium, more details are available in their published work.
This protein is predicted to be membranous by TOPCONS.
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No binding partner found
The reference OMIM entry for this protein is 604576
Chromosome 14 open reading frame 1; c14orf1
CLONING
By searching an EST database and screening a human testis cDNA library, Veitia et al. (1999) obtained a novel full-length cDNA, which they designated C14ORF1, with multiple potential transcription start points. The C14ORF1 cDNA encodes a basic transmembrane protein of approximately 157 amino acids that has 98% sequence identity with the homologous mouse protein. Northern blot analysis revealed expression of a 1.35-kb C14ORF1 transcript in all tissues and cancer cell lines tested, with strongest expression in testis and some cell lines. The authors noted that C14ORF1 expression was almost undetectable in normal colon mucosa and peripheral blood leukocytes but was highly expressed in a colorectal adenocarcinoma and several leukocyte-derived cell lines.MAPPING
By radiation hybrid analysis, Veitia et al. (1999) mapped the C14ORF1 gene to chromosome 14q24, a region involved in renal cell and colon carcinoma as well as meningioma and neuroblastoma. ... More on the omim web site
March 3, 2020: Protein entry updated
Automatic update: Entry updated from uniprot information.
Oct. 20, 2018: Protein entry updated
Automatic update: OMIM entry 604576 was added.
Oct. 19, 2018: Additional information
Initial protein addition to the database. This entry was referenced in Bryk and co-workers. (2017).